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Scientific studies have proven that knockdown of ULK inhibits autophagosome formation. Mice with defects in ULK1 and ULK2 die in 24 h right after birth [41]. When ULK1 is expressed in mammalian cells, ULK2 isn't necessary for autophagy. Nonetheless, when ULK1 expression is inhibited, ULK2 can compensate for the functionality of ULK1 in regulating a